{"id":2085,"date":"2025-09-15T08:14:30","date_gmt":"2025-09-15T08:14:30","guid":{"rendered":"https:\/\/whmnews.ir\/En\/?p=2085"},"modified":"2025-09-15T08:14:30","modified_gmt":"2025-09-15T08:14:30","slug":"could-a-simple-vitamin-reverse-the-worlds-most-common-liver-disease","status":"publish","type":"post","link":"https:\/\/whmnews.ir\/En\/index.php\/2025\/09\/15\/could-a-simple-vitamin-reverse-the-worlds-most-common-liver-disease\/","title":{"rendered":"Could a Simple Vitamin Reverse the World\u2019s Most Common Liver Disease?"},"content":{"rendered":"<p style=\"text-align: justify;\"><strong>Could a Simple Vitamin Reverse the World\u2019s Most Common Liver Disease?<\/strong><\/p>\n<p style=\"text-align: justify;\"><strong>MiR-93 promotes fatty liver disease, but vitamin B3 can counteract its effects. This discovery suggests a new treatment approach.<\/strong><\/p>\n<p style=\"text-align: justify;\">Roughly 30% of people worldwide are affected by metabolic-associated fatty liver disease (MASLD), a condition that until recently lacked targeted therapies. In an important breakthrough, scientists have identified a genetic factor that worsens the disease, and notably, the FDA-approved compound shown to be most effective against this factor is vitamin B3.<\/p>\n<p style=\"text-align: justify;\">A global first was achieved by a collaborative research group led by Professor Jang Hyun Choi of the Department of Life Sciences at UNIST, together with Professor Hwayoung Yun from the College of Pharmacy and Research Institute for Drug Development at Pusan National University (PNU) and Professor Neung Hwa Park from Ulsan University Hospital (UUH). Their work revealed the critical role of microRNA-93 (miR-93), a molecule expressed in the liver, as a genetic regulator influencing the onset and progression of MASLD.<\/p>\n<p style=\"text-align: justify;\"><strong>Role of miR-93 in liver function<\/strong><\/p>\n<p style=\"text-align: justify;\">MiR-93 is a type of\u00a0RNA\u00a0found in hepatocytes that suppresses the activity of specific target genes. Researchers detected unusually high levels of miR-93 in both human patients with fatty liver disease and in experimental animal models. Molecular studies showed that miR-93 drives lipid buildup, inflammation, and fibrosis by blocking the expression of SIRT1, a gene essential for regulating lipid metabolism in liver cells.<\/p>\n<p style=\"text-align: justify;\">When scientists used gene-editing techniques to block miR-93 production in mice, they observed major reductions in liver fat accumulation, along with improved\u00a0insulin\u00a0sensitivity and liver function markers. In contrast, mice engineered to overexpress miR-93 displayed more severe impairments in liver metabolism.<\/p>\n<p style=\"text-align: justify;\"><strong>Vitamin B3 as a therapeutic candidate<\/strong><\/p>\n<p style=\"text-align: justify;\">Furthermore, screening 150 FDA-approved drugs revealed that niacin (vitamin B3) most effectively suppresses miR-93. Mice treated with niacin showed a significant decrease in hepatic miR-93 levels and a notable increase in SIRT1 activity. The activated SIRT1 restored disrupted lipid metabolism pathways, thereby normalizing liver lipid homeostasis.<\/p>\n<p style=\"text-align: justify;\">The research team explained, \u201cThis study precisely elucidates the molecular origin of MASLD and demonstrates the potential for repurposing an already approved vitamin compound to modulate this pathway, which has high translational clinical relevance.\u201d<\/p>\n<p style=\"text-align: justify;\">They added, \u201cGiven that niacin is a well-established and safe medication used to treat hyperlipidemia, it holds promise as a candidate for combination therapies targeting miRNA pathways in MASLD.\u201d<\/p>\n<p style=\"text-align: justify;\"><strong>\u00a0<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Could a Simple Vitamin Reverse the World\u2019s Most Common Liver Disease? MiR-93 promotes fatty liver disease, but vitamin B3 can counteract its effects. This discovery suggests a new treatment approach. Roughly 30% of people worldwide are affected by metabolic-associated fatty liver disease (MASLD), a condition that until recently lacked targeted therapies. In an important breakthrough, [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":2086,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14],"tags":[663],"class_list":["post-2085","post","type-post","status-publish","format-standard","has-post-thumbnail","category-vitamin-properties","tag-could-a-simple-vitamin-reverse-the-worlds-most-common-liver-disease"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.1 (Yoast SEO v24.1) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Could a Simple Vitamin Reverse the World\u2019s Most Common Liver Disease? - whmnews<\/title>\n<meta name=\"description\" content=\"Could a Simple Vitamin Reverse the World\u2019s Most Common Liver Disease?\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/whmnews.ir\/En\/index.php\/2025\/09\/15\/could-a-simple-vitamin-reverse-the-worlds-most-common-liver-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Could a Simple Vitamin Reverse the World\u2019s Most Common Liver Disease?\" \/>\n<meta property=\"og:description\" content=\"Could a Simple Vitamin Reverse the World\u2019s Most Common Liver Disease?\" \/>\n<meta property=\"og:url\" content=\"https:\/\/whmnews.ir\/En\/index.php\/2025\/09\/15\/could-a-simple-vitamin-reverse-the-worlds-most-common-liver-disease\/\" \/>\n<meta property=\"og:site_name\" content=\"whmnews\" \/>\n<meta property=\"article:published_time\" content=\"2025-09-15T08:14:30+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/whmnews.ir\/En\/wp-content\/uploads\/2025\/09\/Could-a-Simple-Vitamin-Reverse-the-Worlds-Most-Common-Liver-Disease.png\" \/>\n\t<meta property=\"og:image:width\" content=\"598\" \/>\n\t<meta property=\"og:image:height\" content=\"335\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Roza News\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Roza News\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/whmnews.ir\/En\/index.php\/2025\/09\/15\/could-a-simple-vitamin-reverse-the-worlds-most-common-liver-disease\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/whmnews.ir\/En\/index.php\/2025\/09\/15\/could-a-simple-vitamin-reverse-the-worlds-most-common-liver-disease\/\"},\"author\":{\"name\":\"Roza News\",\"@id\":\"https:\/\/whmnews.ir\/En\/#\/schema\/person\/77fef232f03e0a43eb2c2ecc12e4de2e\"},\"headline\":\"Could a Simple Vitamin Reverse the World\u2019s Most Common Liver Disease?\",\"datePublished\":\"2025-09-15T08:14:30+00:00\",\"dateModified\":\"2025-09-15T08:14:30+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/whmnews.ir\/En\/index.php\/2025\/09\/15\/could-a-simple-vitamin-reverse-the-worlds-most-common-liver-disease\/\"},\"wordCount\":400,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/whmnews.ir\/En\/#organization\"},\"image\":{\"@id\":\"https:\/\/whmnews.ir\/En\/index.php\/2025\/09\/15\/could-a-simple-vitamin-reverse-the-worlds-most-common-liver-disease\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/whmnews.ir\/En\/wp-content\/uploads\/2025\/09\/Could-a-Simple-Vitamin-Reverse-the-Worlds-Most-Common-Liver-Disease.png\",\"keywords\":[\"Could a Simple Vitamin Reverse the World\u2019s Most Common Liver Disease?\"],\"articleSection\":[\"Vitamin Properties\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/whmnews.ir\/En\/index.php\/2025\/09\/15\/could-a-simple-vitamin-reverse-the-worlds-most-common-liver-disease\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/whmnews.ir\/En\/index.php\/2025\/09\/15\/could-a-simple-vitamin-reverse-the-worlds-most-common-liver-disease\/\",\"url\":\"https:\/\/whmnews.ir\/En\/index.php\/2025\/09\/15\/could-a-simple-vitamin-reverse-the-worlds-most-common-liver-disease\/\",\"name\":\"Could a Simple Vitamin Reverse the World\u2019s Most Common Liver Disease? 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